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Meanings of secretory granule in English
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.
Thus the secretorygranule-specific sulfated molecule is a proteoglycan with chondroitin sulfate side chains.
2
The molecular mechanisms governing secretorygranule maturation are largely unknown.
3
This process is mediated by secretorygranule exocytosis.
4
The single secretorygranule of the sperm fuses at multiple points with the overlying plasma membrane.
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We further demonstrate that HID-1 deficiency prevented secretorygranule maturation by blocking homotypic fusion of immature secretory granules.
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Presumably all of the proteins secreted by the regulated secretorygranule pathway share some common property that targets them to the secretorygranule.
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Here, we show that excess granules evading exocytosis are degraded via direct fusion with lysosomes, a secretorygranule-specific autophagic process known as crinophagy.
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However, the molecular steps that regulate secretorygranule movement and membrane fusion as well as the role of the cytoskeleton are still poorly understood.
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Prolactin and galanin colocalize in the same secretorygranule, the expression of both proteins is extremely sensitive to the estrogen status of the animal.
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These findings suggest a role for Munc18-2 and the microtubule network in the regulation of secretorygranule dynamics in mast cells.
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Ultrastructurally, the cytoplasm of the tumor cells contained various sized secretorygranules.
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Thus, the composition of secretions from individual secretorygranules is regulated.
13
The vesicles were identified as secretorygranules by their content in immunoreactive serotonin.
14
Morphological analysis revealed the presence of intact chromaffin cells with well-preserved secretorygranules.
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Ciliated cells are characterized with light and dense secretorygranules in supernuclear cytoplasm.
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Our data identify a novel player during the early maturation of immature secretorygranules.