A gene that suppresses the phenotypic expression of another gene (especially of a mutant gene)
1 The NF1 gene is a classic example for a tumour suppressor gene .
2 Thus, DCC represents the most promising candidate tumor suppressor gene from 18q.
3 The tumor suppressor gene p53 is activated by reactive oxygen species-generating agents.
4 These data strongly support the hypothesis that BRCA1 is a tumor suppressor gene .
5 Objective: To determine the expression of tumor suppressor gene PRDM1 in lung cancers.
6 These data suggest that Tes functions as a tumor suppressor gene in vivo.
7 The TP53 tumor suppressor gene is mutated in the majority of human cancers.
8 These observations have led to classify LKB1 as tumour suppressor gene .
9 This suggests that a tumor suppressor gene maps in this region.
10 Hypermethylation-mediated tumor suppressor gene silencing plays a crucial role in tumorigenesis.
11 Mutations in the VHL tumor suppressor gene predispose individuals to highly vascularized tumors.
12 PTEN is a tumor suppressor gene that is frequently mutated in human tumors.
13 Whereas a putative tumor suppressor gene , we did not detect AJAP1 gene mutations.
14 The nm23 gene is a putative tumour and metastasis suppressor gene .
15 Inactivation of the tumor suppressor gene p53 is frequently associated with ovarian cancer.
16 The p53 tumor suppressor gene frequently is mutated in many forms of human carcinomas.
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