1
Methods: Several methodologies are currently being used for ex vivo Treg expansion.
2
Consequently, methods to expand Tregs for therapeutic use are of great interest.
3
The mechanisms of action and cellular targets for Treg-mediated suppression remain controversial.
4
More human Tregs may be required to suppress the stronger xenogeneic response.
5
The implications of our data for models of Treg selection are discussed.
6
Tregs also down-regulated classical activation of macrophages resulting in reduced TNF-alpha production.
7
In addition, this CD83 expression is also conserved on expanded human Treg.
8
TRAF6-deficient mice showed a severe defect in the Treg development in thymus.
9
How Ta1 may contribute to the Treg cell ontogeny is not known.
10
This study shows that an IL-12-IFN-gamma axis can suppress tumor-induced Treg proliferation.
11
However, the mechanisms of Treg expansion in inflammatory environments remain unclear.
12
Tregs have been intensively studied in various autoimmune diseases, infections and different cancers.
13
Moreover low Treg cell numbers were observed in untreated patients experiencing HLH flares.
14
The Treg increase was unrelated to weight loss or metabolic improvement.
15
In HIV infection, Tregs play major roles, both beneficial and detrimental.
16
Tregs prevent autoimmune disease, maintain immune homeostasis and modulate protective responses against infection.
