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1 Costings were estimated for different geographical coverage levels using non-linear cost functions.
2 Data was analyzed individually and by population pharmacokinetic methods, using non-linear mixed effect modeling.
3 A one-compartmental model was used to fit the data using non-linear mixed effects modeling.
4 The curves are represented by exponentials of polynomials whose coefficients are adjusted using non-linear least-squares minimization.
5 The parameter identification method is more accurate and significantly faster computationally than commonly used non-linear , non-convex methods.
6 Using non-linear models, we found that higher BMI was associated with increased risk of EADC even within the normal BMI.
7 Plasma concentration samples from 505 subjects enrolled in 8 clinical studies were analyzed using non-linear mixed-effects modeling.
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