Costings were estimated for different geographical coverage levels using non-linear cost functions.

Data was analyzed individually and by population pharmacokinetic methods, using non-linear mixed effect modeling.

A one-compartmental model was used to fit the data using non-linear mixed effects modeling.

The curves are represented by exponentials of polynomials whose coefficients are adjusted using non-linear least-squares minimization.

The parameter identification method is more accurate and significantly faster computationally than commonly used non-linear, non-convex methods.

Using non-linear models, we found that higher BMI was associated with increased risk of EADC even within the normal BMI.

Plasma concentration samples from 505 subjects enrolled in 8 clinical studies were analyzed using non-linear mixed-effects modeling.