1
Population PK analysis was performed by non-linear mixed-effect modelling using NONMEM.
2
A one-compartment model with first-order absorption was fitted to the data using NONMEM software.
3
A population pharmacokinetic analysis was conducted using NONMEM 7.
4
Concentrations were modelled using NONMEM and associated with treatment outcomes using unpaired t-tests or Pearson's rho correlations.
5
The data were analyzed using NONMEM software.
6
Plasma concentration versus time course was described either by a one-compartment model or by linear splines using NONMEM.
7
Pharmacokinetic studies were performed for a period of 28 days, and population modeling was performed using NONMEM software.
8
Most of the time, modelling was performed for descriptive purposes, with rich rather than sparse data and using NONMEM software.
9
Blood samples were collected at day 3-5 of treatment, and pharmacokinetics parameters were evaluated using NONMEM® software.