Significados de associate loci en inglés

Statistical signals were found that associate loci with environmental parameters, and these loci behave atypically in comparison with the theoretical distribution for neutral loci.

More recently, genome-wide association studies have also pointed to disease risk- associated loci.

Background: AF- associated loci span broad genomic regions that may contain multiple susceptibility signals.

We identified candidate genes for 18 associated loci through detailed annotation.

Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance.

This enables systematic identification and prioritisation of likely causal variants and genes across all published trait- associated loci.

In contrast, comparable efficiencies of inducing homologous donor-based genome editing were observed at disease- associated loci in iPSCs.

Linkage analysis identified 2 disease- associated loci.

While multiple studies support a role for genetic variation in CFS, genome-wide efforts to identify associated loci remain unexplored.

The identification of nine novel neuroticism- associated loci will drive forward future work on the neurobiology of neuroticism and related phenotypes.

We find that migraine has a shared genetic basis with a large number of traits, indicating pervasive pleiotropy at migraine- associated loci.

Objectives: To define further genetic risk loci for sarcoidosis, we used the Immunochip for a candidate gene association study of immune- associated loci.

Furthermore, we confirm the linkage of disease to a number of previously described lupus- associated loci, demonstrating that they are relatively background independent.

We explored biological links between genes in the associated loci using Ingenuity Pathway Analysis that emphasized their roles in embryonic development and function.

We identify 34 lncRNA- associated loci that are conserved between birds and mammals and validate 12 of these in chicken.

True complex disease- associated loci often exert modest effects, so their delineation currently requires integration of diverse phenotypic data from large studies to ensure robust meta-analyses.