Undesired limitation of the utility of a technology due to trade-offs in its technical design.
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Authors' conclusions: We identified relatively few, mostly small studies with short-term follow-up and design limitations.
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Careful review of published trials of these interventions reveals design limitations that contributed to their inconclusive findings.
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When the vibrations are dampened, the resulting motion is kept within the design limitations of the structure of the aircraft.
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Among the possible design limitations of CAR-T cells for cancer are unwanted tonic (antigen-independent) signaling and off-target activation.
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We emphasize the linking of clinical results to molecular mechanisms, discuss study design limitations, and offer some recommendations for future directions.
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The report said the plane broke up as a result of "rudder flutter" because the aircraft airspeed exceeded the design limitations.