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1 CS increases EC permeability in vitro and in vivo; however, the underlying mechanism is not well understood.
2 Thrombin, vascular endothelial growth factor, and hydrogen peroxide increased EC permeability, disrupted cell junctions, and induced stress fiber formation.
3 We hypothesized a direct effect of APC to both prevent increased EC permeability and to restore vascular integrity after edemagenic agonists.
4 Trimodality therapy also increased EC - specific apoptosis 2- to 4-fold more than RT alone and reduced microvessel density by 75% to 82%.
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