Six dogs with lornoxicam induced severe gastrointestinal bleeding are described.
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Results: There were no significant differences in inflammation and cartilage degeneration, between control and lornoxicam applied knees.
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Grade 3 inflammatory changes occurred only in one knee in lornoxicam group, at 24 h after injection.
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Immunohistochemical staining and an electrophoretic mobility shift assay were performed to evaluate the effect of lornoxicam on NF-kappaB activation in the corneal tissues.
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In this study, the effects of intraarticular administration of lornoxicam on the synovium and articular cartilage in the rat knee joint were investigated.
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Histopathology examination revealed a reduced immunostaining positive cell density for NF-kappaB in the cornea from lornoxicam-treated mice as well as a diminished inflammatory response.
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Groups of five rats were sacrificed by a lethal injection of ketamine 1st, 2nd, 7th, 14th and 21st days after lornoxicam administration.
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Lornoxicam was administered intraperitoneally daily, beginning one day before irradiation and lasting for seven days.
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Lornoxicam ingestion leads to severe and longlasting gastrointestinal bleeding in the dog and requires immediate intensive therapy.
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Interpretation & conclusion: Lornoxicam did not show significant effect on inflammation on rat synovia in knee joint.