Six dogs with lornoxicam induced severe gastrointestinal bleeding are described.

Results: There were no significant differences in inflammation and cartilage degeneration, between control and lornoxicam applied knees.

Grade 3 inflammatory changes occurred only in one knee in lornoxicam group, at 24 h after injection.

Immunohistochemical staining and an electrophoretic mobility shift assay were performed to evaluate the effect of lornoxicam on NF-kappaB activation in the corneal tissues.

In this study, the effects of intraarticular administration of lornoxicam on the synovium and articular cartilage in the rat knee joint were investigated.

Histopathology examination revealed a reduced immunostaining positive cell density for NF-kappaB in the cornea from lornoxicam-treated mice as well as a diminished inflammatory response.

Groups of five rats were sacrificed by a lethal injection of ketamine 1st, 2nd, 7th, 14th and 21st days after lornoxicam administration.

Lornoxicam was administered intraperitoneally daily, beginning one day before irradiation and lasting for seven days.

Lornoxicam ingestion leads to severe and longlasting gastrointestinal bleeding in the dog and requires immediate intensive therapy.

Interpretation & conclusion: Lornoxicam did not show significant effect on inflammation on rat synovia in knee joint.