1
These correlations may be explained by chromosomal destabilization, which can mediate gene amplification and can result in cellular lethality.
2
Thus, pharmacological GCs mediate gene expression by favoring GR homodimer occupancy at classic palindromic sites at the expense of monomeric binding.
3
MBD2 is a subunit of the NuRD complex that is postulated to mediate gene repression via recruitment of the complex to methylated DNA.
4
In this study, we investigated the potential of this vector, pEPI-eGFP, to mediate gene transfer in hematopoietic progenitor cell lines and primary human cells.
5
In initial studies, the optimal conditions for retrovirus- mediated gene transfer were determined.
6
Cortical administration of Rp-8-Cl-cAMPS attenuated the experience-dependent activation of CRE- mediated gene transcription.
7
Hepatocytes that self-assemble into spheroids can be transduced through adenovirus- mediated gene transfer.
8
This Review focuses primarily on E2A- mediated gene regulation during B-lymphocyte development.
9
The triplet codon repeats lead to heterochromatin- mediated gene silencing and loss of frataxin.
10
Adenoviral- mediated gene delivery targeted its expression mainly to intestinal epithelial cells.
11
Reduction of β-catenin availability using small interfering RNA- mediated gene silencing inhibited ERKs phosphorylation.
12
Adenovirus- mediated gene therapy has been limited by immune reaction and target genes selection.
13
These new developments in formulation technology enhance the potential for polymeric nanoparticle- mediated gene therapy.
14
These results combined suggest that Nrf3 is a negative regulator of ARE- mediated gene expression.
15
These data provide insights into GATA-1- mediated gene regulation in vivo.
16
Nuclear receptor- mediated gene expression is regulated by corepressors and coactivators.