Neither modulating pyrimidine metabolism nor purine salvage has similar effects.
2
Current clinical trials are evaluating the role of non-fluorinated pyrimidine agents in an adjuvant setting.
3
The resulting deuterosugar is converted into pyrimidine nucleosides and incorporated into DNA using standard protocols.
4
Reducing aspartate availability for pyrimidine synthesis restricted cancerous proliferation.
5
They are activated by both pyrimidine and purine nucleotides.
Uso de pyrimidines en inglés
1
Extracellular purines and pyrimidines have major effects on cardiac rhythm and contraction.
2
The malaria parasite is unable to salvage pyrimidines and relies on de novo biosynthesis for survival.
3
Exogenous pyrimidines reverse DNA damage and rescue growth.
4
The availability of selenium-containing nucleic acids for crystallographic phasing offers an attractive alternative to the commonly used halogenated pyrimidines.
5
HIV-1 resistance is likely to limit the therapeutic efficacy of acyclic 6-substituted pyrimidines if they are used as monotherapy.
6
Skipping of short internal exons was reversed both in vitro and in vivo when purines in the upstream polypyrimidine tract were replaced by pyrimidines.
7
Notably, cell death results from pyrimidine depletion rather than ammonia toxicity, as CPS1 enables an unconventional pathway of nitrogen flow from ammonia into pyrimidines.
8
We report here the structural impact of these lesions within two decanucleotide sequences containing either 5'- and 3'-flanking pyrimidines or purines.