However, SFRP4 does not control glucose homeostasis and β-cell mass in mice.
2
The islet β-cell is unusual in that glucose lacks an extracellular receptor.
3
This effect was not associated with enhanced β-cell proliferation or mass.
4
Type 2 diabetes incidence increases with age, while β-cell replication declines.
5
This was paralleled by an increase in β-cell proliferation and mass.
1
The pancreaticbetacell is the major source of circulating insulin in adult mammals.
2
Glucocorticoid doses, insulin sensitivity and pancreaticbetacell function were compared among these groups.
3
In males, insulin resistance progresses to a severe form of diabetes accompanied by pancreaticbetacell failure.
4
APX-115 significantly improved pancreaticbetacell function by decreased fasting blood glucose levels and increased insulin levels.
5
These female SLE patients with hyperglycemia were characterized by insulin resistance and reduced pancreaticbetacell function, and they were relatively young.
Uso de beta cell em inglês
1
However, its association with insulin resistance and betacell function remains controversial.
2
Hence, our results implicate both CTL and cytokines in betacell destruction.
3
Insulin resistance and betacell function were assessed with the homeostasis model.
4
ATT also extended islet viability in mice after streptozotocin-induced betacell toxicity.
5
Objective: Study the role of hyperglycemia-induced betacell loss on grafted islet destruction.
6
Insulin resistance and betacell function were assessed by using the homeostasis model.
7
Background: Exercise has a betacell preserving effect in patients with type 2 diabetes.
8
New therapeutic strategies to improve betacell function are therefore believed to be beneficial.
9
The secondary outcome of the study is rate of loss of betacell function.
10
However, its mechanism in which way with MGO induced betacell death remains unknown.
11
Five of 13 tested were positive for betacell autoantibodies.
12
The pancreatic betacell is the major source of circulating insulin in adult mammals.
13
In addition, we sought to determine whether the drug would affect betacell function.
14
Glucocorticoid doses, insulin sensitivity and pancreatic betacell function were compared among these groups.
15
Specific immunoreactivity was found in the membranes of betacell-secretory granules and cytoplasmic membranes.
16
Ad-hTGFbeta enhanced differentiation and proliferation in the betacell line or islets without causing apoptosis.