Methods and results: Herein, we demonstrate that mouse and humancardiomyocytes express the TWEAK receptor Fn14.
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The effect of purified KCNQ1 antibodies on humancardiomyocytes derived from induced pluripotent stem cells was then studied.
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Currently, the immaturity of humancardiomyocytes derived from stem cells limits their utility for regenerative medicine and biological research.
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Moreover, whether these Ca(2+) release channels are present and play a critical role in humancardiomyocytes remains to be defined.
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We validated the technique on humancardiomyocytes either freshly isolated or selectively excised from fixed sections of human myocardium by Laser Capture Microdissection.
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We validate optical actuation by virally introducing optogenetic drivers in rat and humancardiomyocytes or through the modular use of dedicated light-sensitive somatic 'spark' cells.