Resistance to tumor necrosis factor-related apoptosis- inducingligand (TRAIL) is a major limitation for its clinical use.
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Here we describe a novel member of the TNF family designated APRIL (for a proliferation- inducingligand).
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A proliferation- inducingligand (APRIL) is a new tumor necrosis factor family member implicated in tumor cell proliferation.
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Background: Tumor necrosis factor-related apoptosis- inducingligand (TRAIL) induces apoptosis in malignant cells but not in normal cells.
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Purpose: B-lymphocyte stimulator and a proliferation- inducingligand regulate B-cell homeostasis and immunoglobulin production and are overexpressed in B-cell malignancies.
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Tumor necrosis factor-related apoptosis inducedligand (TRAIL) is an important apoptosis inducer in a variety of tumor cells.
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ER stress induces the upregulation of tumor necrosis factor-related apoptosis inducingligand (TRAIL) receptor and opening new horizons for therapeutic research.
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TNF-related apoptosis- inducingligand (TRAIL) is a type II integral membrane protein that interacts with multiple receptors and cell types including neurons.
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In addition, overexpression of RTVP-1 rendered glioma cells more resistant to the apoptotic effect of tumor necrosis factor-related apoptosis- inducingligand and serum deprivation.
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Here we show that tumor necrosis factor-related apoptosis- inducingligand (TRAIL) plays a critical role in the NK cell-mediated and IFN-gamma-dependent tumor surveillance.
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We have previously reported tumor necrosis factor-related apoptosis- inducingligand (TRAIL) immunoreactivity within pulmonary vascular lesions from patients with idiopathic PAH and animal models.
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One such anti-neoplastic protein is tumour necrosis factor-related apoptosis- inducingligand (TRAIL) because it induces apoptosis in cancerous cells, but not in non-transformed cells.
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Tumor necrosis factor-related apoptosis- inducingligand (TRAIL), a tumor necrosis factor superfamily member, targets death receptors and selectively kills malignant cells while leaving normal cells unaffected.