Background: Previous studies have found that children born with a non-syndromic orofacialcleft have lower-than-average educational attainment.
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Over 80% of infants had an isolated orofacialcleft.
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Conclusions: To summarize, the findings suggest that individuals with an orofacialcleft show undisturbed emotion regulation and recognition.
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Conclusions: Maternal smoking and medication use is associated with orofacialcleft risk as well as medication use is with spina bifida.
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We investigated maternal NAT2 phenotype and the interaction with smoking and medication use periconceptionally on orofacialcleft and spina bifida risk in offspring.
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Conclusion: A low vitamin B(12) and PLP concentration in mothers increased the risk of orofacialclefts in the offspring.
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Here we review recent advances in genetic epidemiological approaches to complex traits and their applications to studies of nonsyndromic orofacialclefts.
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Orofacialclefts are one of the most common birth defects in humans with a prevalence of 1:700.
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Genome-wide association studies (GWAS) for orofacialclefts have identified several susceptibility regions, but have largely focused on non-Hispanic White populations in developed countries.
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Objective: The hearing status of children with orofacialclefts was analysed using objective hearing tests over an average of 38.7 months following soft palate closure.