1
In unstressed cells, p53 is maintained at low levels by the ubiquitin-proteasome pathway.
2
In this study, we demonstrate that IRE1a interacts with BiP in unstressed cells and dissociates from BiP in the course of cartilage development.
3
In unstressed cells, DnaK localizes to multiple, dynamic foci, but relocalizes to focal protein aggregates during stationary phase or upon expression of aggregating peptides.
4
This effect is mirrored by enhanced p53 protein levels in both unstressed cells and cells exposed to p53-activating stress agents.
5
These data indicate that JFK is a critical negative regulator of p53 and represents a pathway for the maintenance of p53 levels in unstressed cells.