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Apramycin, an aminoglycosideantibiotic, has a unique chemical structure that evades almost all resistance mechanisms including the RNA methyltransferases frequently encountered in carbapenemase-producing clinical isolates.
2
These findings identify a previously undescribed genomic island that confers resistance to multiple aminoglycosideantibiotics.
3
Hair cells are sensitive to death from exposure to therapeutic drugs with ototoxic side effects, including aminoglycosideantibiotics and cisplatin.
4
Inflammation and the aminoglycosideantibiotics used to treat neonatal sepsis cause smooth muscle relaxation, but their contribution to PDA is unknown.