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Background: Prosthetic reconstruction may be a promising treatment for peri-acetabular malignant bonetumour; however, it is associated with a high complication rate.
2
Herein we investigated the genetic events of 17 GCTBs including benign and malignant variants and the methylation profiles of 122 bonetumour samples including GCTBs.
3
Reports of primary sacral bonetumours in children are scarce.
4
Primary bonetumours and tumour-like lesions in children have not been reported from Zaria.
5
The purpose of this paper is to describe 16 children with primary sacral bonetumours.
6
All sacral bonetumours, with the exception of Ewing's sarcoma are very rare in childhood.
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Conclusion: This study has shown that, primary bonetumours are relatively uncommon in children in our setting.
8
Material and methods: We performed a descriptive, retrospective, cross sectioned clinical trial in the BoneTumour Department.
9
There were 23 primary malignant bonetumours, four metastatic tumours and four locally advanced primary tumours of the rectum.
10
Osteosarcomas are aggressive bonetumours with a high degree of genetic heterogeneity, which has historically complicated driver gene discovery.
11
The use of extendible distal femoral replacements is a relatively new treatment alternative for malignant bonetumours in growing individuals.
12
Unsupervised clustering of DNA methylation profiles revealed that malignant H3.3-mutated tumours are distinct from their benign counterpart, and other bonetumours.
13
Materials and methods: A retrospective review of histopathology reports of 40 children with bonetumours and tumour-like lesions in 11 years of age.
14
Methods: We retrospectively analyzed 11 patients with peri-acetabular malignant bonetumours treated by personalized 3D-printed hemipelvic prostheses after en bloc resection between 2015 and 2016.