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A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery.
Brooks's case is the first time such a mediator has been used.
2
Court appointed mediator Daniel Pollack said McGill had spoken out of place.
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BP said it had appointed an independent mediator to oversee damage claims.
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Diplomats said that all sides had accepted Mr Obasanjo as a mediator.
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Results indicate that parental investment is an important mediator at both levels.
1
Differential expression of 5 genes encoding different members of the mediatorcomplex was disclosed in this analysis.
2
We found that paxillin interacts with cohesin and the mediatorcomplex, which have been shown to mediate long-range chromosomal looping.
3
As an example we describe isolation of the mammalian Mediatorcomplex from HeLa S3 cells.
4
This gene encodes a subunit of the Mediatorcomplex that modulates the expression of RNA polymerase II-dependent genes.
5
The multiprotein Mediatorcomplex is a coactivator required for transcriptional activation of RNA polymerase II transcribed genes by DNA binding transcription factors.
Использование термина endogenous mediator на английском
1
Taken together, these data suggest that KGF is an important endogenousmediator of normal hair follicle growth, development, and differentiation.
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Future experiments and clinical trial may help defining circumstances under which inhibiting or augmenting endogenousmediators may be a helpful adjunctive therapy for sepsis.