In this study we determine systemic comorbidities associated with lichen sclerosus in men.

Bullous lichen sclerosus is a rare variant that can occur in both genital and extragenital LS.

Men with lichen sclerosus were more likely to have hypertension, hyperlipidemia and diabetes, and to use tobacco products.

A 2-hit mechanism implicating local and systemic factors for lichen sclerosus related urethral stricture disease development and progression is hypothesized.

Results: Of the 1,151 men in the database 81 (7.0%) were noted to have lichen sclerosus related urethral stricture disease.

Conclusions: Lichen sclerosus related urethral stricture disease is associated with chronic systemic diseases.

Purpose: Lichen sclerosus is a chronic, inflammatory skin condition of the genitalia of unknown origin that accounts for nearly 10% of urethral stricture disease.