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Genetic predisposition would appear to be a very important modifier of risk.
2
On subset analysis, the type of presenting symptoms was an effect modifier.
3
The governor had just made a joke about a potential dangling modifier.
4
Gating modifier toxins may constitute useful hits for the treatment of HypoPP.
5
HP twins study suggests that modifier genes influence severity but not penetrance.
Использование термина modifier gene на английском
1
Our study reveals Nrf2 as a novel modifiergene of sepsis that determines survival by mounting an appropriate innate immune response.
2
Here we show that the PKD1 gene can act as a disease causing and a disease modifiergene in ADPKD patients.
3
The estrogen metabolizing gene CYP1B1 is a strong candidate as a modifiergene in female PAH patients.
4
HP twins study suggests that modifiergenes influence severity but not penetrance.
5
This finding suggests that modifiergenes contribute to FPAH clinical expression.
6
Objectives: We intended to identify and pharmaceutically target BMPR2 modifiergenes to improve PAH.
7
In this study, we evaluated the putative role of variants in many candidate modifiergenes.
8
This review will summarize the methods and results thus far in the identification of atherosclerosis- modifiergenes.
9
Incomplete penetrance suggests the existence of modifiergenes.
10
However, patients present with wide clinical heterogeneity, suggesting that modifiergenes play a role in determining severity.
11
Our results also highlight the BMP regulation pathway as a good candidate for identification of new modifiergenes.
12
Family history data are critical in the study of hereditary cancer syndromes and the identification of cancer modifiergenes.
13
However, this does not explain the phenotypic variability, which is likely modulated by environmental factors, modifiergenes or age-dependent expression.
14
We propose a model of how HbF modifiergenes and disease pathology interact to shape HbF levels measured in patients.
15
A genome scan of the backcross to FVB suggests that one or more modifiergenes are present on chromosome 5.
16
With the exception of one mild missense DAX1 mutation, genotype-phenotype correlations have been elusive, suggesting an important role for modifiergenes.