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We used a leaky stochastic accumulator to model the neu …
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Amplification and overexpression of the neu gene have been found in several human adenocarcinomas.
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Together these studies indicate that p185neu expression is a common feature of human lung tumors.
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Down-modulation of the normal cell-surface neu protein was inefficient.
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Survival of animals was significantly prolonged after immunization with vaccines encoding neu together with the costimulatory molecules.
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One patient who underwent LT is waiting for ENU due to post-cryotherapy complication.
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Here we review progress in ENU mutagenesis screening, with an emphasis on creating mouse models for human disorders.
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Our results demonstrate that the expression of differentiation antigens in ENU-induced experimental neurinomas parallels the results reported for human neurinomas.
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ENU is a toxin and carcinogen as well as a mutagen, and strains differ in their susceptibility to its effects.
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We report on a battery of behavioral screening tests that successfully identified several neurobehavioral mutants among a large-scale ENU-mutagenized mouse population.
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Here we introduce a method for real-time identification of N-ethyl-N-nitrosourea-induced mutations that cause phenotypes in mice.