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We used a leaky stochastic accumulator to model the neu …
2
Amplification and overexpression of the neu gene have been found in several human adenocarcinomas.
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Together these studies indicate that p185neu expression is a common feature of human lung tumors.
4
Down-modulation of the normal cell-surface neu protein was inefficient.
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Survival of animals was significantly prolonged after immunization with vaccines encoding neu together with the costimulatory molecules.
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Here, we compared an H. ducreyi neuA mutant to its wild-type parent in several models of pathogenesis.
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This study demonstrates that intramuscular or intradermal injections of rat neuNT full-length DNA into mice generate anti-p185 autoantibodies.
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We have examined the expression of the neu gene in human non-small cell lung carcinomas using immunoprecipitation and immunohistochemistry.
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The neu is found over-expressed in 20-30% of human breast tumors.
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The recombinant neu differentiation factor-alpha 2 isoform had no significant biological effects in either full or deep partial thickness burns.
11
Retrospective studies suggest that HER2-neu status is a powerful independent prognostic factor in T1a,b node-negative breast cancer.
12
We tested possible down-modulating effects of these monoclonal antibodies on SKBR-3 mammary tumor cells, which express high levels of wild-type human neu protein.
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In this study, we screened overlapping peptides of the entire neu protein and identified six new epitopes recognized by vaccine-induced neu-N-derived T cells.
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Earlier studies have shown that neu transgenic mice exhibit immune tolerance to the neu-expressing tumors similar to what is observed in patients with cancer.
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The transforming genes of 6 other transformants derived from 3 sarcomas did not contain ras family or neu transforming genes.
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No CTL response was evoked in either IL-12-treated or DNA-vaccinated mice, whereas an anti-rat p185neu antibody response was evident in the latter.