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One patient who underwent LT is waiting for ENU due to post-cryotherapy complication.
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Here we review progress in ENU mutagenesis screening, with an emphasis on creating mouse models for human disorders.
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Our results demonstrate that the expression of differentiation antigens in ENU-induced experimental neurinomas parallels the results reported for human neurinomas.
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ENU is a toxin and carcinogen as well as a mutagen, and strains differ in their susceptibility to its effects.
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We report on a battery of behavioral screening tests that successfully identified several neurobehavioral mutants among a large-scale ENU-mutagenized mouse population.
1
Here we introduce a method for real-time identification of N-ethyl-N-nitrosourea-induced mutations that cause phenotypes in mice.
Использование термина neu на английском
1
We used a leaky stochastic accumulator to model the neu …
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Amplification and overexpression of the neu gene have been found in several human adenocarcinomas.
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Together these studies indicate that p185neu expression is a common feature of human lung tumors.
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Down-modulation of the normal cell-surface neu protein was inefficient.
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Survival of animals was significantly prolonged after immunization with vaccines encoding neu together with the costimulatory molecules.
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Here, we compared an H. ducreyi neuA mutant to its wild-type parent in several models of pathogenesis.
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This study demonstrates that intramuscular or intradermal injections of rat neuNT full-length DNA into mice generate anti-p185 autoantibodies.
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We have examined the expression of the neu gene in human non-small cell lung carcinomas using immunoprecipitation and immunohistochemistry.
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The neu is found over-expressed in 20-30% of human breast tumors.
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The recombinant neu differentiation factor-alpha 2 isoform had no significant biological effects in either full or deep partial thickness burns.
11
Retrospective studies suggest that HER2-neu status is a powerful independent prognostic factor in T1a,b node-negative breast cancer.
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We tested possible down-modulating effects of these monoclonal antibodies on SKBR-3 mammary tumor cells, which express high levels of wild-type human neu protein.
13
In this study, we screened overlapping peptides of the entire neu protein and identified six new epitopes recognized by vaccine-induced neu-N-derived T cells.
14
Earlier studies have shown that neu transgenic mice exhibit immune tolerance to the neu-expressing tumors similar to what is observed in patients with cancer.
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The transforming genes of 6 other transformants derived from 3 sarcomas did not contain ras family or neu transforming genes.
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No CTL response was evoked in either IL-12-treated or DNA-vaccinated mice, whereas an anti-rat p185neu antibody response was evident in the latter.