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To determine Scx function, we produced a mutant nullallele.
4
Therefore, we have generated a hypomorphic allele of Rad51c in addition to a nullallele.
5
The first mutation deletes a large portion of the coding sequence, generating a nullallele.
6
We used gene targeting in embryonic stem cells to introduce an IL-1 beta nullallele in mice.
7
We now present detailed functional analyses of Zfp281 using a genetically ablated nullallele in mouse ESCs.
8
Here we have studied ADAR2-mediated RNA editing by generating mice that are homozygous for a targeted functional nullallele.
9
The wide prevalence of this nullallele in this population is probably due to the effects of a small founder population.
10
Similar circumstances existed when the CMAH nullallele was polymorphic in ancestral hominins, just before the divergence of Homo from australopithecines.
11
A nullallele of yeast CCP1 gene encoding CcP was created by one-step gene disruption method in a diploid yeast strain.
12
Furthermore, suppression was not observed when the suppressor allele was present on a plasmid and the chromosomal dnaA was a nullallele.
13
We have generated a nullallele of the mouse Msx1 homeobox gene by insertion of an nlacZ reporter gene into its homeobox.
14
Consistent with these phenotypes, mice carrying the fgfr1 nullallele survived significantly longer than those without fgfr1 deletion.
15
GSTT1 nullallele frequency was 45.78%, which was significantly higher than that in Caucasians and African-American.
16
In a gene trap screen we recovered a mouse mutant line in which an insertion generated a nullallele of the Brd4 gene.