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However, SFRP4 does not control glucose homeostasis and β-cell mass in mice.
2
The islet β-cell is unusual in that glucose lacks an extracellular receptor.
3
This effect was not associated with enhanced β-cell proliferation or mass.
4
Type 2 diabetes incidence increases with age, while β-cell replication declines.
5
This was paralleled by an increase in β-cell proliferation and mass.
1
However, its association with insulin resistance and betacell function remains controversial.
2
Hence, our results implicate both CTL and cytokines in betacell destruction.
3
Insulin resistance and betacell function were assessed with the homeostasis model.
4
ATT also extended islet viability in mice after streptozotocin-induced betacell toxicity.
5
Objective: Study the role of hyperglycemia-induced betacell loss on grafted islet destruction.
Usage of pancreatic beta cell in английском
1
The pancreaticbetacell is the major source of circulating insulin in adult mammals.
2
Glucocorticoid doses, insulin sensitivity and pancreaticbetacell function were compared among these groups.
3
In males, insulin resistance progresses to a severe form of diabetes accompanied by pancreaticbetacell failure.
4
APX-115 significantly improved pancreaticbetacell function by decreased fasting blood glucose levels and increased insulin levels.
5
These female SLE patients with hyperglycemia were characterized by insulin resistance and reduced pancreaticbetacell function, and they were relatively young.
6
GLIS3, which is involved in pancreaticbetacell development and insulin gene expression, is known for its association with fasting glucose levels.
7
Obesity-related insulin resistance represents the core component of the metabolic syndrome, promoting glucose intolerance, pancreaticbetacell failure and type 2 diabetes.
8
In conclusion, our data suggest that a 48-h hyperglycaemic period results in an increased response of the pancreaticbetacell to low glucose.
9
Using in situ imaging and hormone assays, we further show that JB253 bestows light sensitivity upon rodent and human pancreaticbetacell function.
10
Through their actions on ATP-sensitive potassium (KATP) channels, sulfonylureas boost insulin release from the pancreaticbetacell mass to restore glucose homeostasis.
11
The pancreaticbetacell normally maintains a stable balance among insulin secretion, insulin production, and insulin degradation to keep optimal intracellular stores of the hormone.
12
The pancreaticbetacell functions as a key regulator of blood glucose levels by integrating a variety of signals in response to changing metabolic demands.
13
The assessment of pancreaticbetacell function in humans is challenging because of a complex interplay between insulin secretion, insulin sensitivity and hepatic insulin extraction.
14
Type 1A diabetes (T1D) results from autoimmunity targeted at a limited number of molecules that are expressed in the pancreaticbetacell.
15
Several isoforms of the leptin receptor are expressed in pancreaticbetacells.
16
In pancreaticbetacells, this would lead to less insulin secretion and thereby diabetes.