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This favorable survival result was seen in most prespecified subgroups for pralatrexate.
2
These results indicate that pralatrexate is generally well tolerated and effective in Japanese patients with relapsed or refractory peripheral T-cell lymphoma.
3
A trend toward improvement in OS favoring pralatrexate was observed with an HR of 0.84 (95% confidence interval: 0.61-1.14) in the intent-to-treat population.
4
Pralatrexate is a novel antifolate approved in the USA for the treatment of relapsed or refractory peripheral T-cell lymphoma.
5
Pralatrexate, which has already received FDA's orphan drug status to treat T-cell lymphoma, is being tested as a treatment for large B-cell lymphoma.
Использование термина pdx на английском
1
Western blot analysis was used to detect the changes in PDX-1 expression.
2
The PDX model was used successfully to test targeted drugs in vivo.
3
This a-to-β conversion was not caused by activating Pdx1 in the later glucagon-expressing state.
4
In addition, RNAi technology was used to specifically knock down the endogenous PDX-1 expression.
5
A specific serum assay for PDX is not commercially available.
6
Conclusions: In LC, islets undergo hypertrophy and exhibit paradoxical expression of insulin and PDX-1.
7
This PDX model was generated from a previously untreated HNSCC.
8
This was determined by repeated measures linear regression statistical analysis in four different PDX models.
9
And they are not the first animals to work at PDX, the airport's call letters.
10
We cultured three PDX and three clinical patient specimens with 100% success rate.
11
Methods: A series of truncated PDX-1 mutants were constructed.
12
PDX studies extend this mechanistic relationship to CCOC tissues.
13
PDXs also varied in their sensitivity to chemotherapeutic agents.
14
Recently, CTCs have been used to generate PDX experimental models of breast and prostate cancer.
15
However, the optimal dose and schedule of LV in PDX treatment has not yet been established.
16
Notably, variable PDX growth rates over time might have implications for the interpretation of translational studies.