Utilitzem cookies
Aquest lloc web utilitza cookies per a oferir-vos la informació més rellevant. Si vosté continua navegant, accepta aquestes cookies.
Aquest lloc web utilitza cookies per a oferir-vos la informació més rellevant. Si vosté continua navegant, accepta aquestes cookies.
Ho sabíeu?
Podeu fer doble clic en una paraula per a buscar-la a TermGallery.
Podeu fer doble clic en una paraula per a buscar-la a TermGallery.
Significats de mediator complex en anglès
espanyol
mediador A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery.
Veure'n mésTermes relacionats
Ús de mediator complex en anglès
1
Differential expression of 5 genes encoding different members of the mediator complex was disclosed in this analysis.
2
We found that paxillin interacts with cohesin and the mediator complex, which have been shown to mediate long-range chromosomal looping.
3
As an example we describe isolation of the mammalian Mediator complex from HeLa S3 cells.
4
This gene encodes a subunit of the Mediator complex that modulates the expression of RNA polymerase II-dependent genes.
5
The multiprotein Mediator complex is a coactivator required for transcriptional activation of RNA polymerase II transcribed genes by DNA binding transcription factors.
6
Taken together, our findings identify a new subunit of the mammalian Mediator and shed new light on the architecture of the mammalian Mediator complex.
7
Eukaryotic transcription activators stimulate the expression of specific sets of target genes through recruitment of co-activators such as the RNA polymerase II-interacting Mediator complex.
8
There is unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease.
9
Here we identify one of these proteins, encoded by the previously uncharacterized AK000411 open reading frame, as a new subunit of the mammalian Mediator complex.
10
The Mediator complex-associated cyclin-dependent kinase CDK8 has been implicated in human disease, particularly in colorectal cancer where it has been reported as a putative oncogene.