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Significados de mediator complex en inglés

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A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery.

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Uso de mediator complex en inglés
1
Differential expression of 5 genes encoding different members of the mediator complex was disclosed in this analysis.
Pubmed
2
We found that paxillin interacts with cohesin and the mediator complex, which have been shown to mediate long-range chromosomal looping.
Pubmed
3
As an example we describe isolation of the mammalian Mediator complex from HeLa S3 cells.
Pubmed
4
This gene encodes a subunit of the Mediator complex that modulates the expression of RNA polymerase II-dependent genes.
Pubmed
5
The multiprotein Mediator complex is a coactivator required for transcriptional activation of RNA polymerase II transcribed genes by DNA binding transcription factors.
Pubmed
6
Taken together, our findings identify a new subunit of the mammalian Mediator and shed new light on the architecture of the mammalian Mediator complex.
Pubmed
7
Eukaryotic transcription activators stimulate the expression of specific sets of target genes through recruitment of co-activators such as the RNA polymerase II-interacting Mediator complex.
Pubmed
8
There is unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease.
Pubmed
9
Here we identify one of these proteins, encoded by the previously uncharacterized AK000411 open reading frame, as a new subunit of the mammalian Mediator complex.
Pubmed
10
The Mediator complex-associated cyclin-dependent kinase CDK8 has been implicated in human disease, particularly in colorectal cancer where it has been reported as a putative oncogene.
Pubmed
Translations for mediator complex
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