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Significados de mediator complex en inglés

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A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery.

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        Uso de mediator complex en inglés
        1
        Differential expression of 5 genes encoding different members of the mediator complex was disclosed in this analysis.
        Pubmed
        2
        We found that paxillin interacts with cohesin and the mediator complex, which have been shown to mediate long-range chromosomal looping.
        Pubmed
        3
        As an example we describe isolation of the mammalian Mediator complex from HeLa S3 cells.
        Pubmed
        4
        This gene encodes a subunit of the Mediator complex that modulates the expression of RNA polymerase II-dependent genes.
        Pubmed
        5
        The multiprotein Mediator complex is a coactivator required for transcriptional activation of RNA polymerase II transcribed genes by DNA binding transcription factors.
        Pubmed
        6
        Taken together, our findings identify a new subunit of the mammalian Mediator and shed new light on the architecture of the mammalian Mediator complex.
        Pubmed
        7
        Eukaryotic transcription activators stimulate the expression of specific sets of target genes through recruitment of co-activators such as the RNA polymerase II-interacting Mediator complex.
        Pubmed
        8
        There is unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease.
        Pubmed
        9
        Here we identify one of these proteins, encoded by the previously uncharacterized AK000411 open reading frame, as a new subunit of the mammalian Mediator complex.
        Pubmed
        10
        The Mediator complex-associated cyclin-dependent kinase CDK8 has been implicated in human disease, particularly in colorectal cancer where it has been reported as a putative oncogene.
        Pubmed
        Translations for mediator complex
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