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Significats de mediator complex en anglès
espanyol
mediador A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery.
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Sinònims
Examples for "mediator"
Examples for "mediator"
1
Brooks's case is the first time such a mediator has been used.
2
Court appointed mediator Daniel Pollack said McGill had spoken out of place.
3
BP said it had appointed an independent mediator to oversee damage claims.
4
Diplomats said that all sides had accepted Mr Obasanjo as a mediator.
5
Results indicate that parental investment is an important mediator at both levels.
1
Taken together, these data suggest that KGF is an important endogenous mediator of normal hair follicle growth, development, and differentiation.
2
Future experiments and clinical trial may help defining circumstances under which inhibiting or augmenting endogenous mediators may be a helpful adjunctive therapy for sepsis.
Ús de mediator complex en anglès
1
Differential expression of 5 genes encoding different members of the mediator complex was disclosed in this analysis.
2
We found that paxillin interacts with cohesin and the mediator complex, which have been shown to mediate long-range chromosomal looping.
3
As an example we describe isolation of the mammalian Mediator complex from HeLa S3 cells.
4
This gene encodes a subunit of the Mediator complex that modulates the expression of RNA polymerase II-dependent genes.
5
The multiprotein Mediator complex is a coactivator required for transcriptional activation of RNA polymerase II transcribed genes by DNA binding transcription factors.
6
Taken together, our findings identify a new subunit of the mammalian Mediator and shed new light on the architecture of the mammalian Mediator complex.
7
Eukaryotic transcription activators stimulate the expression of specific sets of target genes through recruitment of co-activators such as the RNA polymerase II-interacting Mediator complex.
8
There is unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease.
9
Here we identify one of these proteins, encoded by the previously uncharacterized AK000411 open reading frame, as a new subunit of the mammalian Mediator complex.
10
The Mediator complex-associated cyclin-dependent kinase CDK8 has been implicated in human disease, particularly in colorectal cancer where it has been reported as a putative oncogene.