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1 Randomized trials that compare new drugs with current standard treatments are needed.
2 Methods: We conducted a systematic review of published and unpublished randomized trials .
3 Results: Six randomized trials and two published meta-analyses of follow-up were obtained.
4 Results obtained in randomized trials may not easily generalize to target populations.
5 Randomized trials of sequenced biochemotherapies should shed further light on this issue.
6 Randomized trials should evaluate whether PCI could improve survival of advanced LCNECs.
7 Several randomized trials of androgen supplementation in older men have been undertaken.
8 These preliminary findings from this uncontrolled study require confirmation in randomized trials .
9 Few randomized trials have been performed to evaluate other CAM fertility treatments.
10 Eligible studies include randomized trials with bevacizumab in patients with breast cancer.
11 This conclusion needs to be confirmed by future large randomized trials .
12 Bias against publishing nonsignificant results is a problem even for large randomized trials .
13 Prospective, randomized trials are needed to firmly assess this possible difference.
14 Results: Of ten randomized trials identified, five were considered for analysis.
15 Data synthesis: Twenty-eight articles from 26 randomized trials met eligibility criteria.
16 Ongoing randomized trials of selenium supplements may help to further evaluate this issue.
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