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1
Randomized
trials
that compare new drugs with current standard treatments are needed.
2
Methods: We conducted a systematic review of published and unpublished
randomized
trials
.
3
Results: Six
randomized
trials
and two published meta-analyses of follow-up were obtained.
4
Results obtained in
randomized
trials
may not easily generalize to target populations.
5
Randomized
trials
of sequenced biochemotherapies should shed further light on this issue.
6
Randomized
trials
should evaluate whether PCI could improve survival of advanced LCNECs.
7
Several
randomized
trials
of androgen supplementation in older men have been undertaken.
8
These preliminary findings from this uncontrolled study require confirmation in
randomized
trials
.
9
Few
randomized
trials
have been performed to evaluate other CAM fertility treatments.
10
Eligible studies include
randomized
trials
with bevacizumab in patients with breast cancer.
11
This conclusion needs to be confirmed by future large
randomized
trials
.
12
Bias against publishing nonsignificant results is a problem even for large
randomized
trials
.
13
Prospective,
randomized
trials
are needed to firmly assess this possible difference.
14
Results: Of ten
randomized
trials
identified, five were considered for analysis.
15
Data synthesis: Twenty-eight articles from 26
randomized
trials
met eligibility criteria.
16
Ongoing
randomized
trials
of selenium supplements may help to further evaluate this issue.