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Meanings of conserve residue in English

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Usage of conserve residue in English
1
Protein-altering mutations were significantly enriched for changes at highly conserved residues.
Pubmed
2
Other conserved residues act sterically to provide a structural basis for polyamine specificity.
Pubmed
3
Mutational studies of these conserved residues highlight their functional importance.
Pubmed
4
All variants affect highly conserved residues in the SCN5A protein.
Pubmed
5
Most pathological missense mutations in human L1 affect conserved residues.
Pubmed
6
We also demonstrate the importance of these conserved residues for proteolysis by an archaeal proteasome.
Pubmed
7
The variants disrupt highly conserved residues across the protein.
Pubmed
8
In contrast, the E2 protein's transactivation domain does not have extensive surfaces of highly conserved residues.
Pubmed
9
Here, we investigate the extent to which these conserved residues are clustered in three-dimensional protein structures.
Pubmed
10
To assess the significance of conserved residues, various point mutations and deletions were introduced into this region.
Pubmed
11
This protein contains all but one conserved residues known to be involved in beta-galactoside binding in galectins.
Pubmed
12
These results suggested that the conserved residue Tyr-194 is critical for catalytic function of the novel AHL-lactonase.
Pubmed
13
Conserved residues from all three monomers contribute to each of the three active sites within the dUTPase.
Pubmed
14
Therefore, detection of the conserved residues using phylogenetic analysis is a general approach to predict functionally critical residues.
Pubmed
15
KCNJ8-S422L involves a highly conserved residue and was absent in 1,200 reference alleles.
Pubmed
16
BRIP1 p.R848H alters a highly conserved residue in the catalytic DNA helicase domain.
Pubmed