Ainda não temos significados para "conserve residue".
1Protein-altering mutations were significantly enriched for changes at highly conserved residues.
2Other conserved residues act sterically to provide a structural basis for polyamine specificity.
3Mutational studies of these conserved residues highlight their functional importance.
4All variants affect highly conserved residues in the SCN5A protein.
5Most pathological missense mutations in human L1 affect conserved residues.
6We also demonstrate the importance of these conserved residues for proteolysis by an archaeal proteasome.
7The variants disrupt highly conserved residues across the protein.
8In contrast, the E2 protein's transactivation domain does not have extensive surfaces of highly conserved residues.
9Here, we investigate the extent to which these conserved residues are clustered in three-dimensional protein structures.
10To assess the significance of conserved residues, various point mutations and deletions were introduced into this region.
11This protein contains all but one conserved residues known to be involved in beta-galactoside binding in galectins.
12These results suggested that the conserved residue Tyr-194 is critical for catalytic function of the novel AHL-lactonase.
13Conserved residues from all three monomers contribute to each of the three active sites within the dUTPase.
14Therefore, detection of the conserved residues using phylogenetic analysis is a general approach to predict functionally critical residues.
15KCNJ8-S422L involves a highly conserved residue and was absent in 1,200 reference alleles.
16BRIP1 p.R848H alters a highly conserved residue in the catalytic DNA helicase domain.