Methods: We undertook unsupervised analyses of RNA-sequencing data of 284 MPMs, with no assumption of discreteness.

Small replicate numbers, discreteness, large dynamic range and the presence of outliers require a suitable statistical approach.

We utilize the discreteness of Dirichlet process prior to cluster signatures that exhibit similar differential expression profiles.

The permutation test performs well for any settings though the discreteness in cluster size must be accounted for.

The discreteness is still more obvious when, instead of old things changing, they cease, or when altogether new things come.

And if speciation unfolds in geological moments, then species in geological time match organisms on our ordinary yearly scales in both distinctness and discreteness.

But, by important contrast, species construct their equally powerful integrity and discreteness by different means that do not require such suppression of upwardly cascading effects.

But its apparent discreteness is due to a failure to distinguish between the silent, unobtrusive working of comparison and the more obvious and self-conscious working.