A dual guide approach improved gene deletion efficacy in both cell types.

CHOP gene deletion in SCs decreased cell death in response to TNF-a.

Quantitative polymerase chain reaction indicated total WASP gene deletion in the proband.

Aromatase gene deletion in female mice exacerbates ischemic brain damage after stroke.

In addition, essential genes were predicted via single gene deletion studies.

Gao was specifically inactivated in pancreatic progenitor cells by pancreatic cell-specific gene deletion.

Lrh-1 gene deletion attenuates cancer cell metabolism in hepatocytes through mitochondrial glutamine processing.

Determining the effect of gene deletion is a fundamental approach to understanding gene function.

The specific inhibitors and gene deletion technologies were used to address the molecular mechanisms.

CLIC4 gene deletion markedly attenuated the development of chronic hypoxia-induced pulmonary hypertension in mice.

In this study, we used gene deletion and complement methods to confirm its putative functions.

Conclusion: NOS2 gene deletion did not affect the inflammatory responses, but reduced the cartilage degradation.

Targeted gene deletion in the producer resulted in a 90% reduced diaminopentane secretion.

Methods: We studied a twin pair with an exon 4 gene deletion in the PGRN gene.

Recently, gene deletion revealed a predominant role of NPR-B in endochondral ossification and development of female reproductive organs.

Thus, our findings show that ubiquitous CSF-1 gene deletion using a Cre-based system recapitulates the expected osteopetrotic phenotype.