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Recent evidence suggests that cellular senescence also may be involved in aging.
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EWS deficiency leads to impaired development and early senescence through unknown mechanisms.
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It has been suggested that this process is responsible for cellular senescence.
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However, the signaling mechanism linking obesity with age-related vascular senescence is unknown.
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Premature and absolute loss of PTEN activity usually tends to cellular senescence.
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He sees it as a matter of re-educating the public and health authorities to see biologicalageing in a new light.
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Thus, drift emerges as a promising biomarker for premature or biologicalageing, and could potentially be used in geriatrics for disease risk prediction.
Usage of biological aging in inglês
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An accelerated rate of biologicalaging could contribute to this increased risk.
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Problem: Epigenetic age indices are markers of biologicalaging determined from DNA methylation patterns.
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A widely used marker of biologicalaging is telomere length.
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This study assessed the contribution of genetic and nongenetic factors to biologicalaging in American Caucasians.
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As the biologicalaging process demonstrates gender-specific characteristics, the analyses were performed separately in males and female.
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These interventions may, however, work through different pathophysiological mechanisms and could differ in their impact on biologicalaging and somatic health.
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Objective: Psychological factors such as the stress of caregiving are emerging as predictors of telomere length, an index of biologicalaging.
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A common mechanism underlying premature declines in health may be accelerated biologicalaging, as reflected by leukocyte telomere length (LTL).
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Background: Depressive and anxiety disorders have shown to be associated to premature or advanced biologicalaging and consequently to adversely impact somatic health.
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During the course of biologicalaging, there is a gradual accumulation of damaged proteins and a concomitant functional decline in the protein degradation system.
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Depression and depressive symptoms are associated with a range of morbidities and mortality, but the extent to which they predict biologicalaging is unclear.
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It has been hypothesized that one way in which lower socioeconomic status (SES) affects health is by increasing the rate of biologicalaging.
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Thus, CR reduces the platelet-derived growth factor-associated signaling cascade, contributing to the postponement of biologicalaging and preservation of a more youthful aortic wall phenotype.
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Accordingly, we sought to develop a metabolomic signature of biologicalaging that could predict changes in physiological function with the convenience of a blood sample.
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This study assessed the association between abuse exposure and shortening of telomere length (TL), a promising molecular marker for biologicalaging, in older victims.
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Biologicalaging is associated with physiological deteriorations, which are partly due to changes in the hormonal profile.